Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 34 | 20 | 9 | 5 | 57 | 39 | +18 | 69 |
| 2 | Orlando City | 34 | 18 | 9 | 7 | 55 | 39 | +16 | 63 |
| 3 | Columbus Crew | 34 | 16 | 9 | 9 | 67 | 46 | +21 | 57 |
| 4 | Philadelphia Union | 34 | 15 | 10 | 9 | 57 | 41 | +16 | 55 |
| 5 | New England | 34 | 15 | 10 | 9 | 58 | 46 | +12 | 55 |
| 6 | Atlanta United | 34 | 13 | 12 | 9 | 66 | 53 | +13 | 51 |
| 7 | Nashville SC | 34 | 13 | 10 | 11 | 39 | 32 | +7 | 49 |
| 8 | New York RB | 34 | 11 | 10 | 13 | 36 | 39 | -3 | 43 |
| 9 | Charlotte | 34 | 10 | 13 | 11 | 45 | 52 | -7 | 43 |
| 10 | Montréal | 34 | 12 | 5 | 17 | 36 | 52 | -16 | 41 |
| 11 | New York City | 34 | 9 | 14 | 11 | 35 | 39 | -4 | 41 |
| 12 | D.C. United | 34 | 10 | 10 | 14 | 45 | 49 | -4 | 40 |
| 13 | Chicago Fire | 34 | 10 | 10 | 14 | 39 | 51 | -12 | 40 |
| 14 | Inter Miami | 34 | 9 | 7 | 18 | 41 | 54 | -13 | 34 |
| 15 | Toronto | 34 | 4 | 10 | 20 | 26 | 59 | -33 | 22 |
Fixtures
| December 10, 2023 | ||
| Columbus Crew | 00:00 | Los Angeles |
Result
| December 3, 2023 | ||
| Los Angeles | 2 - 0 | Houston Dynamo |
| Cincinnati | 2 - 2 | Columbus Crew |
| November 27, 2023 | ||
| Seattle Sounders | 0 - 1 | Los Angeles |
| Houston Dynamo | 1 - 0 | Sporting KC |
| November 26, 2023 | ||
| Cincinnati | 1 - 0 | Philadelphia Union |
| Orlando City | 0 - 0 | Columbus Crew |
| November 13, 2023 | ||
| Columbus Crew | 4 - 2 | Atlanta United |
| November 12, 2023 | ||
| Houston Dynamo | 1 - 1 | Real Salt Lake |
| November 11, 2023 | ||
| Seattle Sounders | 1 - 0 | Dallas |
| November 9, 2023 | ||
| New England | 0 - 1 | Philadelphia Union |
| November 8, 2023 | ||
| Nashville SC | 0 - 1 | Orlando City |
| Atlanta United | 4 - 2 | Columbus Crew |
| November 7, 2023 | ||
| Real Salt Lake | 1 - 1 | Houston Dynamo |
| November 6, 2023 | ||
| Vancouver Whitecaps FC | 0 - 1 | Los Angeles |
| Sporting KC | 2 - 1 | St. Louis City |
| November 5, 2023 | ||
| Dallas | 3 - 1 | Seattle Sounders |
| New York RB | 1 - 1 | Cincinnati |
| November 2, 2023 | ||
| Columbus Crew | 2 - 0 | Atlanta United |
| October 31, 2023 | ||
| Seattle Sounders | 2 - 0 | Dallas |
| Orlando City | 1 - 0 | Nashville SC |