Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Inter Miami | 34 | 22 | 8 | 4 | 79 | 49 | +30 | 74 |
| 2 | Columbus Crew | 34 | 19 | 9 | 6 | 72 | 40 | +32 | 66 |
| 3 | Cincinnati | 34 | 18 | 5 | 11 | 58 | 48 | +10 | 59 |
| 4 | Orlando City | 34 | 15 | 7 | 12 | 59 | 50 | +9 | 52 |
| 5 | Charlotte | 34 | 14 | 9 | 11 | 46 | 37 | +9 | 51 |
| 6 | New York City | 34 | 14 | 8 | 12 | 54 | 49 | +5 | 50 |
| 7 | New York RB | 34 | 11 | 14 | 9 | 55 | 50 | +5 | 47 |
| 8 | Montréal | 34 | 11 | 10 | 13 | 48 | 64 | -16 | 43 |
| 9 | Atlanta United | 34 | 10 | 10 | 14 | 46 | 49 | -3 | 40 |
| 10 | D.C. United | 34 | 10 | 10 | 14 | 52 | 70 | -18 | 40 |
| 11 | Toronto | 34 | 11 | 4 | 19 | 40 | 61 | -21 | 37 |
| 12 | Philadelphia Union | 34 | 9 | 10 | 15 | 62 | 55 | +7 | 37 |
| 13 | Nashville SC | 34 | 9 | 9 | 16 | 38 | 54 | -16 | 36 |
| 14 | New England | 34 | 9 | 4 | 21 | 37 | 74 | -37 | 31 |
| 15 | Chicago Fire | 34 | 7 | 9 | 18 | 40 | 62 | -22 | 30 |
Fixtures
| December 1, 2024 | ||
| Orlando City | 03:30 | New York RB |
| LA Galaxy | 06:00 | Seattle Sounders |
Result
| November 25, 2024 | ||
| LA Galaxy | 6 - 2 | Minnesota United |
| November 24, 2024 | ||
| Orlando City | 1 - 0 | Atlanta United |
| Los Angeles | 1 - 1 | Seattle Sounders |
| New York City | 0 - 2 | New York RB |
| November 10, 2024 | ||
| Inter Miami | 2 - 3 | Atlanta United |
| Orlando City | 1 - 1 | Charlotte |
| Cincinnati | 0 - 0 | New York City |
| November 9, 2024 | ||
| Los Angeles | 1 - 0 | Vancouver Whitecaps FC |
| November 4, 2024 | ||
| Vancouver Whitecaps FC | 3 - 0 | Los Angeles |
| Houston Dynamo | 1 - 1 | Seattle Sounders |
| New York RB | 2 - 2 | Columbus Crew |
| November 3, 2024 | ||
| Minnesota United | 1 - 1 | Real Salt Lake |
| Atlanta United | 2 - 1 | Inter Miami |
| New York City | 3 - 1 | Cincinnati |
| November 2, 2024 | ||
| Colorado Rapids | 1 - 4 | LA Galaxy |
| Charlotte | 0 - 0 | Orlando City |
| October 30, 2024 | ||
| Real Salt Lake | 0 - 0 | Minnesota United |
| Columbus Crew | 0 - 1 | New York RB |
| October 29, 2024 | ||
| Seattle Sounders | 0 - 0 | Houston Dynamo |