Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | PEC Zwolle | 8 | 6 | 1 | 1 | 23 | 10 | +13 | 19 |
| 2 | Eindhoven | 8 | 5 | 3 | 0 | 17 | 7 | +10 | 18 |
| 3 | Heracles Almelo | 7 | 5 | 1 | 1 | 20 | 9 | +11 | 16 |
| 4 | Roda JC Kerkrade | 8 | 4 | 3 | 1 | 15 | 10 | +5 | 15 |
| 5 | NAC Breda | 8 | 4 | 2 | 2 | 12 | 10 | +2 | 14 |
| 6 | VVV-Venlo | 7 | 4 | 1 | 2 | 13 | 13 | +0 | 13 |
| 7 | AZ II | 8 | 4 | 1 | 3 | 16 | 12 | +4 | 13 |
| 8 | Willem II | 7 | 3 | 3 | 1 | 8 | 6 | +2 | 12 |
| 9 | MVV | 7 | 3 | 2 | 2 | 14 | 14 | +0 | 11 |
| 10 | Jong Ajax | 8 | 3 | 2 | 3 | 15 | 13 | +2 | 11 |
| 11 | Almere City | 8 | 3 | 1 | 4 | 10 | 12 | -2 | 10 |
| 12 | Jong PSV | 8 | 2 | 3 | 3 | 9 | 14 | -5 | 9 |
| 13 | ADO Den Haag | 8 | 2 | 2 | 4 | 10 | 14 | -4 | 8 |
| 14 | TOP Oss | 7 | 2 | 1 | 4 | 9 | 11 | -2 | 7 |
| 15 | Dordrecht | 7 | 2 | 1 | 4 | 7 | 11 | -4 | 7 |
| 16 | Telstar | 7 | 2 | 1 | 4 | 5 | 13 | -8 | 7 |
| 17 | Helmond Sport | 7 | 2 | 0 | 5 | 7 | 10 | -3 | 6 |
| 18 | Den Bosch | 8 | 2 | 0 | 6 | 10 | 16 | -6 | 6 |
| 19 | De Graafschap | 8 | 1 | 2 | 5 | 9 | 16 | -7 | 5 |
| 20 | Jong FC Utrecht | 8 | 1 | 2 | 5 | 6 | 14 | -8 | 5 |
Fixtures
| September 23, 2022 | ||
| Dordrecht | 22:00 | MVV |
| VVV-Venlo | 22:00 | Telstar |
| Heracles Almelo | 22:00 | Helmond Sport |
| TOP Oss | 22:00 | Willem II |
| September 30, 2022 | ||
| ADO Den Haag | 21:00 | Jong PSV |
| Almere City | 21:00 | Roda JC Kerkrade |
| Den Bosch | 21:00 | Heracles Almelo |
| Eindhoven | 21:00 | Dordrecht |
| De Graafschap | 21:00 | AZ II |
| Helmond Sport | 21:00 | TOP Oss |
| MVV | 21:00 | Willem II |
| NAC Breda | 21:00 | VVV-Venlo |
| PEC Zwolle | 21:00 | Jong Ajax |
| Telstar | 21:00 | Jong FC Utrecht |
Result
| September 17, 2022 | ||
| Den Bosch | 4 - 1 | TOP Oss |
| September 16, 2022 | ||
| NAC Breda | 3 - 1 | Jong FC Utrecht |
| De Graafschap | 1 - 2 | Almere City |
| Helmond Sport | 2 - 1 | Dordrecht |
| MVV | 4 - 1 | Jong Ajax |
| Eindhoven | 3 - 3 | Roda JC Kerkrade |
| PEC Zwolle | 1 - 2 | ADO Den Haag |
| Telstar | 0 - 3 | Heracles Almelo |
| VVV-Venlo | 1 - 1 | Jong PSV |
| Willem II | 1 - 0 | AZ II |
| September 12, 2022 | ||
| Jong FC Utrecht | 1 - 1 | ADO Den Haag |
| Roda JC Kerkrade | 3 - 2 | De Graafschap |
| Jong PSV | 3 - 1 | Den Bosch |
| AZ II | 2 - 3 | PEC Zwolle |
| Almere City | 1 - 1 | Eindhoven |
| Jong Ajax | 3 - 1 | NAC Breda |