Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | PSV Eindhoven | 7 | 6 | 0 | 1 | 28 | 10 | +18 | 18 |
| 2 | Ajax | 7 | 6 | 0 | 1 | 22 | 5 | +17 | 18 |
| 3 | AZ | 7 | 5 | 2 | 0 | 13 | 5 | +8 | 17 |
| 4 | Feyenoord | 7 | 5 | 1 | 1 | 20 | 9 | +11 | 16 |
| 5 | Twente | 7 | 4 | 1 | 2 | 12 | 5 | +7 | 13 |
| 6 | Heerenveen | 7 | 3 | 3 | 1 | 8 | 7 | +1 | 12 |
| 7 | Sparta Rotterdam | 7 | 3 | 1 | 3 | 9 | 8 | +1 | 10 |
| 8 | RKC Waalwijk | 7 | 2 | 3 | 2 | 15 | 10 | +5 | 9 |
| 9 | Utrecht | 7 | 2 | 3 | 2 | 9 | 10 | -1 | 9 |
| 10 | Excelsior | 7 | 3 | 0 | 4 | 10 | 18 | -8 | 9 |
| 11 | NEC | 7 | 1 | 5 | 1 | 7 | 5 | +2 | 8 |
| 12 | Groningen | 7 | 2 | 2 | 3 | 7 | 12 | -5 | 8 |
| 13 | Go Ahead Eagles | 7 | 2 | 0 | 5 | 10 | 15 | -5 | 6 |
| 14 | Vitesse | 7 | 1 | 2 | 4 | 7 | 16 | -9 | 5 |
| 15 | FC Volendam | 7 | 1 | 2 | 4 | 8 | 21 | -13 | 5 |
| 16 | Fortuna Sittard | 7 | 1 | 1 | 5 | 9 | 17 | -8 | 4 |
| 17 | Cambuur | 7 | 1 | 1 | 5 | 5 | 14 | -9 | 4 |
| 18 | Emmen | 7 | 1 | 1 | 5 | 6 | 18 | -12 | 4 |
Fixtures
| October 1, 2022 | ||
| Cambuur | 17:30 | PSV Eindhoven |
| Groningen | 19:45 | AZ |
| Ajax | 21:00 | Go Ahead Eagles |
| Twente | 22:00 | Vitesse |
| October 2, 2022 | ||
| Fortuna Sittard | 13:15 | FC Volendam |
| Excelsior | 15:30 | Utrecht |
| NEC | 15:30 | Feyenoord |
| RKC Waalwijk | 17:45 | Sparta Rotterdam |
| Emmen | 21:00 | Heerenveen |
| October 7, 2022 | ||
| Groningen | 21:00 | RKC Waalwijk |
| October 8, 2022 | ||
| FC Volendam | 17:30 | Ajax |
| Sparta Rotterdam | 19:45 | Emmen |
| NEC | 22:00 | Excelsior |
| October 9, 2022 | ||
| Go Ahead Eagles | 13:15 | Cambuur |
| Feyenoord | 15:30 | Twente |
| Utrecht | 15:30 | AZ |
| Heerenveen | 17:45 | PSV Eindhoven |
| Vitesse | 21:00 | Fortuna Sittard |
| October 14, 2022 | ||
| Emmen | 21:00 | FC Volendam |
Result
| September 18, 2022 | ||
| AZ | 2 - 1 | Ajax |
| Heerenveen | 2 - 1 | Twente |
| PSV Eindhoven | 4 - 3 | Feyenoord |
| Go Ahead Eagles | 2 - 0 | Emmen |
| September 17, 2022 | ||
| Fortuna Sittard | 1 - 0 | Excelsior |
| RKC Waalwijk | 5 - 1 | Cambuur |
| Vitesse | 1 - 1 | FC Volendam |
| Sparta Rotterdam | 2 - 1 | Groningen |
| September 16, 2022 | ||
| Utrecht | 0 - 0 | NEC |
| September 11, 2022 | ||
| Feyenoord | 3 - 0 | Sparta Rotterdam |
| AZ | 1 - 1 | Twente |
| Cambuur | 0 - 1 | Groningen |
| PSV Eindhoven | 1 - 0 | RKC Waalwijk |
| Utrecht | 1 - 0 | Vitesse |
| September 10, 2022 | ||
| Excelsior | 2 - 1 | Emmen |
| Ajax | 5 - 0 | Heerenveen |
| NEC | 1 - 1 | Fortuna Sittard |
| September 9, 2022 | ||
| FC Volendam | 2 - 3 | Go Ahead Eagles |