Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | SSC Napoli | 7 | 5 | 2 | 0 | 15 | 5 | +10 | 17 |
| 2 | Atalanta | 7 | 5 | 2 | 0 | 11 | 3 | +8 | 17 |
| 3 | Udinese | 7 | 5 | 1 | 1 | 15 | 7 | +8 | 16 |
| 4 | Lazio | 7 | 4 | 2 | 1 | 13 | 5 | +8 | 14 |
| 5 | AC Milan | 7 | 4 | 2 | 1 | 13 | 8 | +5 | 14 |
| 6 | Roma | 7 | 4 | 1 | 2 | 8 | 7 | +1 | 13 |
| 7 | Inter Milan | 7 | 4 | 0 | 3 | 13 | 11 | +2 | 12 |
| 8 | Juventus | 7 | 2 | 4 | 1 | 9 | 5 | +4 | 10 |
| 9 | Torino | 7 | 3 | 1 | 3 | 6 | 7 | -1 | 10 |
| 10 | Fiorentina | 7 | 2 | 3 | 2 | 7 | 6 | +1 | 9 |
| 11 | Sassuolo | 7 | 2 | 3 | 2 | 5 | 8 | -3 | 9 |
| 12 | Spezia | 7 | 2 | 2 | 3 | 7 | 11 | -4 | 8 |
| 13 | Salernitana | 7 | 1 | 4 | 2 | 10 | 8 | +2 | 7 |
| 14 | Empoli | 7 | 1 | 4 | 2 | 6 | 7 | -1 | 7 |
| 15 | Lecce | 7 | 1 | 3 | 3 | 6 | 8 | -2 | 6 |
| 16 | Bologna | 7 | 1 | 3 | 3 | 7 | 10 | -3 | 6 |
| 17 | Verona | 7 | 1 | 2 | 4 | 6 | 13 | -7 | 5 |
| 18 | Monza | 7 | 1 | 1 | 5 | 4 | 14 | -10 | 4 |
| 19 | Cremonese | 7 | 0 | 2 | 5 | 5 | 14 | -9 | 2 |
| 20 | Sampdoria | 7 | 0 | 2 | 5 | 4 | 13 | -9 | 2 |
Fixtures
| October 1, 2022 | ||
| SSC Napoli | 16:00 | Torino |
| Inter Milan | 19:00 | Roma |
| Empoli | 21:45 | AC Milan |
| October 2, 2022 | ||
| Lazio | 13:30 | Spezia |
| Lecce | 16:00 | Cremonese |
| Sampdoria | 16:00 | Monza |
| Sassuolo | 16:00 | Salernitana |
| Atalanta | 19:00 | Fiorentina |
| Juventus | 21:45 | Bologna |
| October 3, 2022 | ||
| Verona | 21:45 | Udinese |
| October 8, 2022 | ||
| Sassuolo | 16:00 | Inter Milan |
| AC Milan | 19:00 | Juventus |
| Bologna | 21:45 | Sampdoria |
| October 9, 2022 | ||
| Torino | 13:30 | Empoli |
| Monza | 16:00 | Spezia |
| Salernitana | 16:00 | Verona |
| Udinese | 16:00 | Atalanta |
| Cremonese | 19:00 | SSC Napoli |
| Roma | 21:45 | Lecce |
| October 10, 2022 | ||
| Fiorentina | 21:45 | Lazio |
Result
| September 18, 2022 | ||
| AC Milan | 1 - 2 | SSC Napoli |
| Roma | 0 - 1 | Atalanta |
| Monza | 1 - 0 | Juventus |
| Fiorentina | 2 - 0 | Verona |
| Cremonese | 0 - 4 | Lazio |
| Udinese | 3 - 1 | Inter Milan |
| September 17, 2022 | ||
| Torino | 0 - 1 | Sassuolo |
| Spezia | 2 - 1 | Sampdoria |
| Bologna | 0 - 1 | Empoli |
| September 16, 2022 | ||
| Salernitana | 1 - 2 | Lecce |
| September 12, 2022 | ||
| Empoli | 1 - 2 | Roma |
| September 11, 2022 | ||
| Juventus | 2 - 2 | Salernitana |
| Lazio | 2 - 0 | Verona |
| Bologna | 2 - 1 | Fiorentina |
| Sassuolo | 1 - 3 | Udinese |
| Lecce | 1 - 1 | Monza |
| Atalanta | 1 - 1 | Cremonese |
| September 10, 2022 | ||
| Sampdoria | 1 - 2 | AC Milan |
| Inter Milan | 1 - 0 | Torino |
| SSC Napoli | 1 - 0 | Spezia |