Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Panathinaikos | 5 | 5 | 0 | 0 | 9 | 1 | +8 | 15 |
| 2 | PAOK | 5 | 3 | 2 | 0 | 5 | 2 | +3 | 11 |
| 3 | Aris | 5 | 3 | 1 | 1 | 8 | 4 | +4 | 10 |
| 4 | AEK Athens | 5 | 3 | 0 | 2 | 8 | 3 | +5 | 9 |
| 5 | Olympiakos | 5 | 2 | 2 | 1 | 7 | 4 | +3 | 8 |
| 6 | Volos NFC | 5 | 2 | 2 | 1 | 7 | 5 | +2 | 8 |
| 7 | Atromitos | 5 | 2 | 2 | 1 | 9 | 5 | +4 | 8 |
| 8 | Panaitolikos | 5 | 2 | 1 | 2 | 6 | 6 | +0 | 7 |
| 9 | Asteras Tripolis | 5 | 0 | 4 | 1 | 4 | 6 | -2 | 4 |
| 10 | OFI | 5 | 1 | 1 | 3 | 4 | 8 | -4 | 4 |
| 11 | PAS Giannina | 5 | 1 | 1 | 3 | 3 | 9 | -6 | 4 |
| 12 | Lamia | 5 | 0 | 3 | 2 | 1 | 5 | -4 | 3 |
| 13 | Levadiakos | 5 | 0 | 2 | 3 | 2 | 7 | -5 | 2 |
| 14 | Ionikos | 5 | 0 | 1 | 4 | 2 | 10 | -8 | 1 |
Fixtures
| October 1, 2022 | ||
| Lamia | 19:30 | Levadiakos |
| October 2, 2022 | ||
| Asteras Tripolis | 15:00 | OFI |
| Olympiakos | 16:00 | Atromitos |
| Volos NFC | 19:30 | Aris |
| PAOK | 21:30 | Panathinaikos |
| October 3, 2022 | ||
| PAS Giannina | 18:00 | Panaitolikos |
| AEK Athens | 20:00 | Ionikos |
| October 8, 2022 | ||
| Panaitolikos | 17:00 | Volos NFC |
| Ionikos | 19:30 | Lamia |
| October 9, 2022 | ||
| OFI | 16:00 | Olympiakos |
| Levadiakos | 16:30 | PAOK |
| Panathinaikos | 19:30 | Asteras Tripolis |
| Aris | 21:15 | AEK Athens |
| October 10, 2022 | ||
| Atromitos | 18:00 | PAS Giannina |
| October 15, 2022 | ||
| Volos NFC | 17:00 | Levadiakos |
| Aris | 20:30 | Ionikos |
| October 16, 2022 | ||
| AEK Athens | 16:00 | Atromitos |
| PAS Giannina | 18:00 | OFI |
| Lamia | 19:30 | Panathinaikos |
| Asteras Tripolis | 20:30 | Panaitolikos |
Result
| September 18, 2022 | ||
| Volos NFC | 2 - 0 | Ionikos |
| Aris | 2 - 1 | Olympiakos |
| OFI | 1 - 1 | PAOK |
| Levadiakos | 1 - 1 | Asteras Tripolis |
| September 17, 2022 | ||
| Panathinaikos | 3 - 0 | PAS Giannina |
| Atromitos | 0 - 0 | Lamia |
| Panaitolikos | 0 - 2 | AEK Athens |
| September 12, 2022 | ||
| PAOK | 1 - 0 | Lamia |
| September 11, 2022 | ||
| Panathinaikos | 2 - 1 | AEK Athens |
| Asteras Tripolis | 0 - 2 | Aris |
| Olympiakos | 1 - 1 | Volos NFC |
| September 10, 2022 | ||
| Ionikos | 1 - 4 | Atromitos |
| PAS Giannina | 2 - 1 | Levadiakos |
| OFI | 1 - 2 | Panaitolikos |
| September 4, 2022 | ||
| Aris | 0 - 0 | PAOK |
| AEK Athens | 2 - 0 | PAS Giannina |
| Volos NFC | 0 - 1 | OFI |
| Atromitos | 1 - 1 | Panaitolikos |