Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Union Berlin | 7 | 5 | 2 | 0 | 15 | 4 | +11 | 17 |
| 2 | Borussia Dortmund | 7 | 5 | 0 | 2 | 9 | 7 | +2 | 15 |
| 3 | SC Freiburg | 7 | 4 | 2 | 1 | 10 | 5 | +5 | 14 |
| 4 | TSG 1899 Hoffenheim | 7 | 4 | 1 | 2 | 12 | 7 | +5 | 13 |
| 5 | Bayern Munich | 7 | 3 | 3 | 1 | 19 | 6 | +13 | 12 |
| 6 | Borussia Mönchengladbach | 7 | 3 | 3 | 1 | 10 | 5 | +5 | 12 |
| 7 | Eintracht Frankfurt | 7 | 3 | 2 | 2 | 14 | 13 | +1 | 11 |
| 8 | Mainz | 7 | 3 | 2 | 2 | 7 | 10 | -3 | 11 |
| 9 | FC Cologne | 7 | 2 | 4 | 1 | 11 | 8 | +3 | 10 |
| 10 | Werder Bremen | 7 | 2 | 3 | 2 | 13 | 12 | +1 | 9 |
| 11 | Augsburg 1907 | 7 | 3 | 0 | 4 | 5 | 10 | -5 | 9 |
| 12 | RB Leipzig | 7 | 2 | 2 | 3 | 9 | 12 | -3 | 8 |
| 13 | Hertha Berlin | 7 | 1 | 3 | 3 | 7 | 9 | -2 | 6 |
| 14 | Schalke 04 | 7 | 1 | 3 | 3 | 8 | 14 | -6 | 6 |
| 15 | Bayer 04 Leverkusen | 7 | 1 | 2 | 4 | 9 | 12 | -3 | 5 |
| 16 | Stuttgart | 7 | 0 | 5 | 2 | 7 | 10 | -3 | 5 |
| 17 | Wolfsburg | 7 | 1 | 2 | 4 | 5 | 12 | -7 | 5 |
| 18 | VFL Bochum | 7 | 0 | 1 | 6 | 5 | 19 | -14 | 1 |
Fixtures
| September 30, 2022 | ||
| Bayern Munich | 21:30 | Bayer 04 Leverkusen |
| October 1, 2022 | ||
| RB Leipzig | 16:30 | VFL Bochum |
| SC Freiburg | 16:30 | Mainz |
| FC Cologne | 16:30 | Borussia Dortmund |
| Eintracht Frankfurt | 16:30 | Union Berlin |
| Wolfsburg | 16:30 | Stuttgart |
| Werder Bremen | 19:30 | Borussia Mönchengladbach |
| October 2, 2022 | ||
| Hertha Berlin | 16:30 | TSG 1899 Hoffenheim |
| Schalke 04 | 18:30 | Augsburg 1907 |
| October 7, 2022 | ||
| TSG 1899 Hoffenheim | 21:30 | Werder Bremen |
| October 8, 2022 | ||
| Bayer 04 Leverkusen | 16:30 | Schalke 04 |
| Mainz | 16:30 | RB Leipzig |
| VFL Bochum | 16:30 | Eintracht Frankfurt |
| Augsburg 1907 | 16:30 | Wolfsburg |
| Borussia Dortmund | 19:30 | Bayern Munich |
| October 9, 2022 | ||
| Borussia Mönchengladbach | 16:30 | FC Cologne |
| Hertha Berlin | 18:30 | SC Freiburg |
| Stuttgart | 20:30 | Union Berlin |
| October 14, 2022 | ||
| Schalke 04 | 21:30 | TSG 1899 Hoffenheim |
| September 18, 2022 | ||
| TSG 1899 Hoffenheim | 0 - 0 | SC Freiburg |
| VFL Bochum | 1 - 1 | FC Cologne |
| Union Berlin | 2 - 0 | Wolfsburg |
| September 17, 2022 | ||
| Borussia Mönchengladbach | 3 - 0 | RB Leipzig |
| Borussia Dortmund | 1 - 0 | Schalke 04 |
| Stuttgart | 1 - 3 | Eintracht Frankfurt |
| Bayer 04 Leverkusen | 1 - 1 | Werder Bremen |
| Augsburg 1907 | 1 - 0 | Bayern Munich |
| September 16, 2022 | ||
| Mainz | 1 - 1 | Hertha Berlin |
| September 11, 2022 | ||
| SC Freiburg | 0 - 0 | Borussia Mönchengladbach |
| FC Cologne | 0 - 1 | Union Berlin |
| September 10, 2022 | ||
| Schalke 04 | 3 - 1 | VFL Bochum |
| RB Leipzig | 3 - 0 | Borussia Dortmund |
| Bayern Munich | 2 - 2 | Stuttgart |
| TSG 1899 Hoffenheim | 4 - 1 | Mainz |
| Eintracht Frankfurt | 0 - 1 | Wolfsburg |
| Hertha Berlin | 2 - 2 | Bayer 04 Leverkusen |
| September 9, 2022 | ||
| Werder Bremen | 0 - 1 | Augsburg 1907 |
| September 4, 2022 | ||
| Borussia Mönchengladbach | 0 - 1 | Mainz |
| Augsburg 1907 | 0 - 2 | Hertha Berlin |