Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Hamburg | 10 | 8 | 0 | 2 | 16 | 6 | +10 | 24 |
| 2 | Darmstadt | 10 | 6 | 3 | 1 | 19 | 11 | +8 | 21 |
| 3 | Paderborn | 10 | 6 | 1 | 3 | 26 | 12 | +14 | 19 |
| 4 | Fortuna Düsseldorf | 10 | 5 | 2 | 3 | 20 | 13 | +7 | 17 |
| 5 | Heidenheim | 10 | 4 | 5 | 1 | 14 | 7 | +7 | 17 |
| 6 | Hannover 96 | 10 | 5 | 2 | 3 | 18 | 14 | +4 | 17 |
| 7 | FC Kaiserslautern | 10 | 3 | 6 | 1 | 19 | 16 | +3 | 15 |
| 8 | Karlsruhe | 10 | 4 | 2 | 4 | 18 | 14 | +4 | 14 |
| 9 | Holstein Kiel | 10 | 3 | 4 | 3 | 17 | 20 | -3 | 13 |
| 10 | Hansa Rostock | 10 | 4 | 1 | 5 | 10 | 14 | -4 | 13 |
| 11 | FC St. Pauli | 10 | 2 | 5 | 3 | 14 | 15 | -1 | 11 |
| 12 | Jahn Regensburg | 10 | 3 | 2 | 5 | 7 | 15 | -8 | 11 |
| 13 | Magdeburg | 10 | 3 | 1 | 6 | 13 | 22 | -9 | 10 |
| 14 | Nürnberg | 10 | 3 | 1 | 6 | 9 | 18 | -9 | 10 |
| 15 | Sandhausen | 10 | 2 | 3 | 5 | 11 | 14 | -3 | 9 |
| 16 | Eintracht Braunschweig | 10 | 2 | 3 | 5 | 11 | 20 | -9 | 9 |
| 17 | Greuther Fürth | 10 | 1 | 5 | 4 | 13 | 18 | -5 | 8 |
| 18 | Arminia Bielefeld | 10 | 2 | 2 | 6 | 13 | 19 | -6 | 8 |
Fixtures
| October 7, 2022 | ||
| Arminia Bielefeld | 19:30 | Karlsruhe |
| Jahn Regensburg | 19:30 | Greuther Fürth |
| October 8, 2022 | ||
| Darmstadt | 14:00 | Fortuna Düsseldorf |
| Hansa Rostock | 14:00 | Paderborn |
| Eintracht Braunschweig | 14:00 | FC St. Pauli |
| Hamburg | 21:30 | FC Kaiserslautern |
| October 9, 2022 | ||
| Heidenheim | 14:30 | Hannover 96 |
| Nürnberg | 14:30 | Holstein Kiel |
| Sandhausen | 14:30 | Magdeburg |
| October 14, 2022 | ||
| Greuther Fürth | 19:30 | Hansa Rostock |
| FC St. Pauli | 19:30 | Hamburg |
| October 15, 2022 | ||
| Fortuna Düsseldorf | 14:00 | Nürnberg |
| Karlsruhe | 14:00 | Darmstadt |
| Magdeburg | 14:00 | Eintracht Braunschweig |
| Hannover 96 | 21:30 | Arminia Bielefeld |
| October 16, 2022 | ||
| Paderborn | 14:30 | Sandhausen |
| Holstein Kiel | 14:30 | Heidenheim |
| FC Kaiserslautern | 14:30 | Jahn Regensburg |
| October 21, 2022 | ||
| Darmstadt | 19:30 | Holstein Kiel |
| Hansa Rostock | 19:30 | FC Kaiserslautern |
| October 2, 2022 | ||
| FC Kaiserslautern | 1 - 1 | Eintracht Braunschweig |
| Magdeburg | 1 - 0 | Jahn Regensburg |
| Karlsruhe | 3 - 0 | Nürnberg |
| October 1, 2022 | ||
| FC St. Pauli | 0 - 0 | Heidenheim |
| Fortuna Düsseldorf | 4 - 1 | Arminia Bielefeld |
| Holstein Kiel | 1 - 1 | Hansa Rostock |
| Greuther Fürth | 1 - 1 | Sandhausen |
| September 30, 2022 | ||
| Hannover 96 | 1 - 2 | Hamburg |
| Paderborn | 1 - 2 | Darmstadt |
| September 18, 2022 | ||
| Greuther Fürth | 2 - 1 | Paderborn |
| Jahn Regensburg | 2 - 0 | FC St. Pauli |
| Heidenheim | 2 - 2 | FC Kaiserslautern |
| September 17, 2022 | ||
| Hamburg | 2 - 0 | Fortuna Düsseldorf |
| Hansa Rostock | 3 - 1 | Magdeburg |
| Darmstadt | 2 - 0 | Nürnberg |
| Arminia Bielefeld | 4 - 2 | Holstein Kiel |
| September 16, 2022 | ||
| Eintracht Braunschweig | 2 - 1 | Karlsruhe |
| Sandhausen | 2 - 3 | Hannover 96 |