Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Millonarios | 20 | 13 | 3 | 4 | 23 | 11 | +12 | 42 |
| 2 | Deportes Tolima | 20 | 12 | 4 | 4 | 29 | 14 | +15 | 40 |
| 3 | Atlético Nacional | 20 | 10 | 6 | 4 | 26 | 15 | +11 | 36 |
| 4 | Independiente … | 20 | 10 | 4 | 6 | 25 | 19 | +6 | 34 |
| 5 | Junior | 20 | 10 | 2 | 8 | 30 | 21 | +9 | 32 |
| 6 | Envigado | 20 | 8 | 7 | 5 | 22 | 21 | +1 | 31 |
| 7 | La Equidad | 20 | 7 | 9 | 4 | 21 | 16 | +5 | 30 |
| 8 | Atlético Bucar… | 20 | 8 | 5 | 7 | 27 | 25 | +2 | 29 |
| 9 | Alianza Petrolera | 20 | 7 | 8 | 5 | 22 | 20 | +2 | 29 |
| 10 | Independiente … | 20 | 7 | 6 | 7 | 29 | 26 | +3 | 27 |
| 11 | Jaguares de Có… | 20 | 8 | 3 | 9 | 26 | 29 | -3 | 27 |
| 12 | Once Caldas | 20 | 6 | 8 | 6 | 18 | 18 | +0 | 26 |
| 13 | Águilas Doradas | 20 | 7 | 4 | 9 | 17 | 26 | -9 | 25 |
| 14 | Deportivo Pereira | 20 | 6 | 5 | 9 | 21 | 26 | -5 | 23 |
| 15 | América de Cali | 20 | 6 | 5 | 9 | 20 | 25 | -5 | 23 |
| 16 | Deportivo Pasto | 20 | 5 | 7 | 8 | 16 | 20 | -4 | 22 |
| 17 | Patriotas Boyacá | 20 | 5 | 6 | 9 | 19 | 23 | -4 | 21 |
| 18 | Cortuluá | 20 | 5 | 5 | 10 | 21 | 27 | -6 | 20 |
| 19 | Deportivo Cali | 20 | 4 | 6 | 10 | 14 | 24 | -10 | 18 |
| 20 | Unión Magdalena | 20 | 2 | 5 | 13 | 8 | 28 | -20 | 11 |
Fixtures
| September 24, 2022 | ||
| Atlético Bucar… | 22:00 | Once Caldas |
| September 25, 2022 | ||
| Millonarios | 00:30 | América de Cali |
| Envigado | 22:00 | Independiente … |
| September 26, 2022 | ||
| Unión Magdalena | 00:05 | Independiente … |
| Alianza Petrolera | 02:10 | Junior |
| Deportes Tolima | 04:15 | Deportivo Pereira |
| September 27, 2022 | ||
| Deportivo Cali | 00:00 | La Equidad |
| Jaguares de Có… | 02:00 | Águilas Doradas |
| Atlético Nacional | 04:05 | Patriotas Boyacá |
| September 28, 2022 | ||
| Deportivo Pasto | 03:00 | Cortuluá |
| September 30, 2022 | ||
| Independiente … | 04:00 | Atlético Nacional |
| October 1, 2022 | ||
| Independiente … | 04:00 | Alianza Petrolera |
| Cortuluá | 22:00 | Atlético Bucar… |
| October 2, 2022 | ||
| Once Caldas | 00:05 | Jaguares de Có… |
| La Equidad | 02:10 | Millonarios |
| Águilas Doradas | 04:15 | Deportes Tolima |
| Deportivo Pereira | 22:00 | Deportivo Pasto |
| October 3, 2022 | ||
| Junior | 00:05 | Deportivo Cali |
| América de Cali | 02:10 | Atlético Nacional |
| Independiente … | 04:15 | Envigado |
Result
| September 23, 2022 | ||
| Independiente … | 2 - 1 | Deportivo Pereira |
| Águilas Doradas | 2 - 0 | Unión Magdalena |
| September 22, 2022 | ||
| Patriotas Boyacá | 0 - 0 | Alianza Petrolera |
| Junior | 0 - 1 | Millonarios |
| América de Cali | 0 - 0 | Deportes Tolima |
| La Equidad | 2 - 3 | Deportivo Pasto |
| September 21, 2022 | ||
| Cortuluá | 2 - 0 | Deportivo Cali |
| Once Caldas | 1 - 0 | Envigado |
| Jaguares de Có… | 0 - 1 | Atlético Bucar… |
| September 20, 2022 | ||
| Deportivo Pereira | 2 - 2 | Águilas Doradas |
| September 19, 2022 | ||
| América de Cali | 2 - 0 | Patriotas Boyacá |
| Atlético Nacional | 3 - 0 | Deportivo Cali |
| September 18, 2022 | ||
| Deportivo Pasto | 2 - 1 | Junior |
| Unión Magdalena | 1 - 0 | Jaguares de Có… |
| Deportes Tolima | 1 - 0 | Once Caldas |
| September 17, 2022 | ||
| Envigado | 3 - 2 | Cortuluá |
| Atlético Bucar… | 2 - 1 | Independiente … |
| Alianza Petrolera | 1 - 2 | La Equidad |
| September 16, 2022 | ||
| América de Cali | 0 - 1 | Deportivo Pereira |
| September 15, 2022 | ||
| Deportivo Cali | 2 - 0 | Deportivo Pasto |