Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Magallanes | 27 | 18 | 5 | 4 | 44 | 20 | +24 | 59 |
| 2 | Cobreloa | 27 | 17 | 6 | 4 | 32 | 18 | +14 | 57 |
| 3 | Unión San Felipe | 26 | 13 | 7 | 6 | 34 | 22 | +12 | 46 |
| 4 | Copiapó | 26 | 12 | 6 | 8 | 39 | 28 | +11 | 42 |
| 5 | Rangers | 27 | 12 | 4 | 11 | 35 | 34 | +1 | 40 |
| 6 | Puerto Montt | 27 | 9 | 11 | 7 | 31 | 28 | +3 | 38 |
| 7 | Santiago Wanderers | 27 | 9 | 9 | 9 | 32 | 33 | -1 | 36 |
| 8 | Universidad Co… | 26 | 8 | 9 | 9 | 33 | 28 | +5 | 33 |
| 9 | Barnechea | 27 | 8 | 8 | 11 | 37 | 37 | +0 | 32 |
| 10 | Deportes Temuco | 26 | 8 | 7 | 11 | 24 | 35 | -11 | 31 |
| 11 | Deportes Iquique | 26 | 7 | 9 | 10 | 27 | 31 | -4 | 30 |
| 12 | Deportes Sant… | 26 | 7 | 8 | 11 | 27 | 32 | -5 | 29 |
| 13 | San Luis de Quillota | 26 | 6 | 10 | 10 | 23 | 36 | -13 | 28 |
| 14 | Santiago Morning | 26 | 6 | 9 | 11 | 28 | 38 | -10 | 27 |
| 15 | Recoleta | 26 | 6 | 8 | 12 | 26 | 34 | -8 | 26 |
| 16 | Melipilla | 26 | 6 | 7 | 13 | 23 | 33 | -10 | 25 |
| 17 | Fernández Vial | 26 | 3 | 15 | 8 | 19 | 27 | -8 | 24 |
Fixtures
| September 24, 2022 | ||
| Barnechea | 18:30 | Melipilla |
| Santiago Morning | 21:00 | Rangers |
| September 25, 2022 | ||
| Deportes Iquique | 18:30 | Universidad Co… |
| Fernández Vial | 21:00 | Copiapó |
| Santiago Wanderers | 21:00 | Recoleta |
| September 26, 2022 | ||
| Deportes Sant… | 02:30 | Puerto Montt |
| Cobreloa | 23:30 | Unión San Felipe |
| September 27, 2022 | ||
| Deportes Temuco | 02:00 | San Luis de Quillota |
| October 1, 2022 | ||
| Puerto Montt | 23:30 | Santiago Morning |
| Copiapó | 23:30 | Rangers |
| October 3, 2022 | ||
| Unión San Felipe | 02:30 | Magallanes |
| Melipilla | 02:30 | Fernández Vial |
| Recoleta | 21:30 | Deportes Sant… |
| Barnechea | 21:30 | Santiago Wanderers |
| October 4, 2022 | ||
| San Luis de Quillota | 02:30 | Deportes Iquique |
| Universidad Co… | 02:30 | Deportes Temuco |
| October 8, 2022 | ||
| Santiago Wanderers | 23:30 | Cobreloa |
| Deportes Temuco | 23:30 | Recoleta |
| October 9, 2022 | ||
| Magallanes | 21:00 | Melipilla |
| Rangers | 21:00 | Universidad Co… |
Result
| September 15, 2022 | ||
| Magallanes | 1 - 1 | Santiago Morning |
| Recoleta | 0 - 1 | Cobreloa |
| September 13, 2022 | ||
| Melipilla | 0 - 1 | Deportes Temuco |
| Puerto Montt | 0 - 1 | Fernández Vial |
| Copiapó | 4 - 2 | Deportes Sant… |
| Universidad Co… | 2 - 1 | Barnechea |
| Rangers | 0 - 2 | Deportes Iquique |
| September 10, 2022 | ||
| Unión San Felipe | 2 - 3 | Santiago Wanderers |
| September 8, 2022 | ||
| Santiago Morning | 1 - 2 | Recoleta |
| San Luis de Quillota | 0 - 3 | Puerto Montt |
| September 7, 2022 | ||
| Barnechea | 0 - 1 | Cobreloa |
| Deportes Iquique | 0 - 0 | Copiapó |
| Deportes Temuco | 1 - 0 | Unión San Felipe |
| Deportes Sant… | 2 - 1 | Rangers |
| Fernández Vial | 1 - 1 | Magallanes |
| September 6, 2022 | ||
| Santiago Wanderers | 2 - 2 | Melipilla |
| August 31, 2022 | ||
| Melipilla | 1 - 2 | San Luis de Quillota |
| Cobreloa | 2 - 1 | Deportes Iquique |
| Unión San Felipe | 1 - 0 | Universidad Co… |