Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Racing Club | 14 | 8 | 6 | 0 | 25 | 10 | +15 | 30 |
| 2 | River Plate | 14 | 9 | 2 | 3 | 31 | 12 | +19 | 29 |
| 3 | Defensa y Justicia | 14 | 7 | 4 | 3 | 26 | 19 | +7 | 25 |
| 4 | Argentinos Juniors | 14 | 7 | 4 | 3 | 21 | 16 | +5 | 25 |
| 5 | Gimnasia La Plata | 14 | 7 | 3 | 4 | 24 | 20 | +4 | 24 |
| 6 | Newell's Old Boys | 14 | 7 | 2 | 5 | 17 | 15 | +2 | 23 |
| 7 | Sarmiento | 14 | 6 | 3 | 5 | 17 | 24 | -7 | 21 |
| 8 | Banfield | 14 | 5 | 4 | 5 | 18 | 15 | +3 | 19 |
| 9 | Unión | 14 | 5 | 2 | 7 | 11 | 13 | -2 | 17 |
| 10 | San Lorenzo | 14 | 3 | 6 | 5 | 15 | 17 | -2 | 15 |
| 11 | Atlético Tucumán | 14 | 2 | 5 | 7 | 13 | 23 | -10 | 11 |
| 12 | Talleres de Có… | 14 | 3 | 2 | 9 | 9 | 21 | -12 | 11 |
| 13 | Platense | 14 | 2 | 4 | 8 | 12 | 23 | -11 | 10 |
| 14 | Atlético Patronato | 14 | 3 | 1 | 10 | 10 | 25 | -15 | 10 |
Fixtures
| July 30, 2022 | ||
| Talleres de Có… | 02:00 | Unión |
| September 13, 2022 | ||
| Vélez Sarsfield | 22:30 | Central Córdob… |
| September 21, 2022 | ||
| Central Córdob… | 02:30 | Gimnasia La Plata |
| September 24, 2022 | ||
| Huracán | 01:00 | Banfield |
| Godoy Cruz | 01:00 | Boca Juniors |
| Defensa y Justicia | 19:00 | Atlético Patronato |
| Sarmiento | 19:00 | Arsenal |
| Lanús | 21:30 | San Lorenzo |
| September 25, 2022 | ||
| River Plate | 00:00 | Talleres de Có… |
| Independiente | 02:30 | Newell's Old Boys |
| Rosario Central | 21:30 | Platense |
| Gimnasia La Plata | 21:30 | Tigre |
| September 26, 2022 | ||
| Racing Club | 00:00 | Unión |
| Atlético Tucumán | 02:30 | Estudiantes |
| Vélez Sarsfield | 02:30 | Barracas Central |
| September 27, 2022 | ||
| Aldosivi | 01:00 | Central Córdob… |
| Colón | 03:30 | Argentinos Juniors |
| September 29, 2022 | ||
| Barracas Central | 21:30 | Gimnasia La Plata |
Result
| September 21, 2022 | ||
| Atlético Patronato | 0 - 0 | Rosario Central |
| September 20, 2022 | ||
| Estudiantes | 1 - 2 | Defensa y Justicia |
| Argentinos Juniors | 1 - 2 | Atlético Tucumán |
| Boca Juniors | 0 - 0 | Huracán |
| Unión | 0 - 1 | Independiente |
| September 19, 2022 | ||
| Arsenal | 3 - 0 | Aldosivi |
| Platense | 0 - 1 | Racing Club |
| Talleres de Có… | 2 - 0 | Colón |
| Banfield | 1 - 2 | Lanús |
| September 18, 2022 | ||
| San Lorenzo | 0 - 1 | River Plate |
| Tigre | 2 - 0 | Vélez Sarsfield |
| Newell's Old Boys | 0 - 1 | Sarmiento |
| September 17, 2022 | ||
| Barracas Central | 3 - 1 | Godoy Cruz |
| September 16, 2022 | ||
| Gimnasia La Plata | 2 - 0 | Arsenal |
| Atlético Tucumán | 1 - 1 | Talleres de Có… |
| Defensa y Justicia | 2 - 1 | Argentinos Juniors |
| Rosario Central | 1 - 1 | Estudiantes |
| September 15, 2022 | ||
| Lanús | 0 - 1 | Boca Juniors |
| River Plate | 1 - 2 | Banfield |