Standing
| # | Team | MP | W | D | L | F | A | G | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Comunicaciones | 16 | 9 | 3 | 4 | 28 | 15 | +13 | 30 |
| 2 | Ituzaingó | 16 | 8 | 4 | 4 | 19 | 15 | +4 | 28 |
| 3 | Colegiales | 16 | 8 | 3 | 5 | 22 | 19 | +3 | 27 |
| 4 | Villa San Carlos | 16 | 7 | 4 | 5 | 23 | 16 | +7 | 25 |
| 5 | Cañuelas | 16 | 7 | 4 | 5 | 22 | 16 | +6 | 25 |
| 6 | Fénix | 16 | 6 | 6 | 4 | 17 | 14 | +3 | 24 |
| 7 | Defensores Unidos | 16 | 6 | 5 | 5 | 22 | 21 | +1 | 23 |
| 8 | Deportivo Armenio | 16 | 5 | 8 | 3 | 17 | 17 | +0 | 23 |
| 9 | Talleres Remedios | 16 | 6 | 4 | 6 | 20 | 20 | +0 | 22 |
| 10 | Argentino Quilmes | 16 | 5 | 6 | 5 | 21 | 18 | +3 | 21 |
| 11 | JJ Urquiza | 16 | 4 | 8 | 4 | 16 | 17 | -1 | 20 |
| 12 | Dock Sud | 16 | 5 | 5 | 6 | 18 | 21 | -3 | 20 |
| 13 | Acassuso | 16 | 4 | 7 | 5 | 19 | 20 | -1 | 19 |
| 14 | Deportivo Merlo | 16 | 4 | 4 | 8 | 10 | 17 | -7 | 16 |
| 15 | Los Andes | 16 | 2 | 9 | 5 | 15 | 21 | -6 | 15 |
| 16 | UAI Urquiza | 16 | 4 | 3 | 9 | 17 | 27 | -10 | 15 |
| 17 | San Miguel | 16 | 3 | 3 | 10 | 11 | 23 | -12 | 12 |
Fixtures
| September 24, 2022 | ||
| Colegiales | 20:00 | Talleres Remedios |
| Comunicaciones | 20:00 | Deportivo Armenio |
| Acassuso | 21:30 | Defensores Unidos |
| Cañuelas | 21:30 | Dock Sud |
| Ituzaingó | 21:30 | Fénix |
| September 25, 2022 | ||
| Argentino Quilmes | 21:30 | Villa San Carlos |
| September 26, 2022 | ||
| JJ Urquiza | 21:30 | UAI Urquiza |
| Los Andes | 21:30 | San Miguel |
| October 1, 2022 | ||
| San Miguel | 03:00 | Ituzaingó |
| Deportivo Armenio | 03:00 | Los Andes |
| Dock Sud | 03:00 | Comunicaciones |
| UAI Urquiza | 03:00 | Cañuelas |
| Villa San Carlos | 03:00 | JJ Urquiza |
| Defensores Unidos | 03:00 | Argentino Quilmes |
| Talleres Remedios | 03:00 | Acassuso |
| Deportivo Merlo | 03:00 | Colegiales |
Result
| September 21, 2022 | ||
| Talleres Remedios | 1 - 1 | Deportivo Merlo |
| September 19, 2022 | ||
| Fénix | 0 - 3 | Los Andes |
| September 18, 2022 | ||
| Defensores Unidos | 1 - 2 | Colegiales |
| Villa San Carlos | 2 - 0 | Acassuso |
| September 17, 2022 | ||
| UAI Urquiza | 0 - 0 | Argentino Quilmes |
| Dock Sud | 1 - 0 | JJ Urquiza |
| Deportivo Armenio | 1 - 0 | Cañuelas |
| San Miguel | 1 - 1 | Comunicaciones |
| September 12, 2022 | ||
| Acassuso | 2 - 0 | UAI Urquiza |
| Los Andes | 3 - 0 | Ituzaingó |
| September 10, 2022 | ||
| Argentino Quilmes | 1 - 1 | Dock Sud |
| Deportivo Merlo | 2 - 2 | Defensores Unidos |
| Colegiales | 4 - 0 | Villa San Carlos |
| Cañuelas | 3 - 1 | San Miguel |
| Comunicaciones | 1 - 1 | Fénix |
| JJ Urquiza | 0 - 1 | Deportivo Armenio |
| September 5, 2022 | ||
| Dock Sud | 2 - 0 | Acassuso |
| Fénix | 1 - 1 | Cañuelas |
| September 4, 2022 | ||
| Villa San Carlos | 1 - 0 | Deportivo Merlo |